Cancer Immunology
The recent breakthroughs in cancer immunology and the development of a newer generation of cancer immunotherapies have opened a brand-new chapter in the war on cancer. The tumor microenvironment composition has a major effect on the response to immunotherapy agents. Thus, an improved understanding of the interactions between the tumor, its microenvironment, and its proximal surroundings is crucial for improving existing treatments and the design of novel immunotherapy strategies.
Dvir Aran
Computational Biologist, analyzing single-cell RNA-seq and clinical data in cancer and other diseases.
Posts
Publications
EpiSort: Enumeration of cell types using targeted bisulfite sequencing
The cellular composition of tumors is now recognized as an essential phenotype, with implications to diagnostic, progression and …
xCell: Digitally portraying the tissue cellular heterogeneity landscape
Tissues are complex milieus consisting of numerous cell types. Several recent methods have attempted to enumerate cell subsets from …
Comprehensive analysis of normal adjacent to tumor transcriptomes
Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in cancer studies. However, little is known …
Widespread parainflammation in human cancer
BACKGROUND Chronic inflammation has been recognized as one of the hallmarks of cancer. We recently showed that parainflammation, a …
Cross-tissue Analysis of Gene and Protein Expression in Normal and Cancer Tissues
The central dogma of molecular biology describes the translation of genetic information from mRNA to protein, but does not specify the …
Embryonic Stem Cell (ES)-Specific Enhancers Specify the Expression Potential of ES Genes in Cancer
Cancers often display gene expression profiles resembling those of undifferentiated cells. The mechanisms controlling these expression …
Systematic pan-cancer analysis of tumour purity
The tumour microenvironment is the non-cancerous cells present in and around a tumour, including mainly immune cells, but also …
